2024/04/10 by Kaitlyn R. Browning, Houra Merrikh · 1 citation
Biochemistry, Genetics and Molecular Biology · #Bacterial Genetics and Biotechnology #Biology #Computational biology #Control of chromosome duplication #DNA #DNA Repair Mechanisms #DNA and Nucleic Acid Chemistry #DNA replication #Eukaryotic DNA replication #Eukaryotic cell #Gene #Genetics #Licensing factor #Minichromosome maintenance #Origin recognition complex #Philosophy #Transcription (linguistics)
paper · doi:10.1146/annurev-biochem-030222-115809
openalex publication_date 2024/04/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
DNA replication and transcription occur in all living cells across all domains of life. Both essential processes occur simultaneously on the same template, leading to conflicts between the macromolecular machines that perform these functions. Numerous studies over the past few decades demonstrate that this is an inevitable problem in both prokaryotic and eukaryotic cells. We have learned that conflicts lead to replication fork reversal, breaks in the DNA, R-loop formation, topological stress, and mutagenesis and can ultimately impact evolution. Recent studies have also provided insight into the various mechanisms that mitigate, resolve, and allow tolerance of conflicts and how conflicts result in pathological consequences across divergent species. In this review, we summarize our current knowledge regarding the outcomes of the encounters between replication and transcription machineries and explore how these clashes are dealt with across species.