2019/09/12 by Babatunde Ekundayo, Franziska Bleichert · 2 citations
Biochemistry, Genetics and Molecular Biology · #DNA Repair Mechanisms #Epigenetics and DNA Methylation #Microtubule and mitosis dynamics
paper · pdf · doi:10.1371/journal.pgen.1008320
openalex publication_date 2019/09/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full complement of chromosomes. DNA synthesis of daughter strands starts at discrete sites, termed replication origins, and proceeds in a bidirectional manner until all genomic DNA is replicated. Despite the fundamental nature of these events, organisms have evolved surprisingly divergent strategies that control replication onset. Here, we discuss commonalities and differences in replication origin organization and recognition in the three domains of life.