Oxidative Stress

2017/04/25 by Helmut Sies, Carsten Berndt, Dean P. Jones · 1 voice · 3,447 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · #Biochemistry #Biology #Cell biology #Chemistry #Genomics, phytochemicals, and oxidative stress #KEAP1 #Neutrophil, Myeloperoxidase and Oxidative Mechanisms #Oxidative phosphorylation #Oxidative stress #Reactive oxygen species #Redox #Redox biology and oxidative stress #Signal transduction #Thioredoxin #Transcription factor

paper · doi:10.1146/annurev-biochem-061516-045037

published in Annual Review of Biochemistry 86(1), 715-748 (Annual Reviews)

openalex publication_date 2017/04/25 · openalex created_date 2022/05/12 · openalex updated_date 2026/08/05

Abstract

Oxidative stress is two sided: Whereas excessive oxidant challenge causes damage to biomolecules, maintenance of a physiological level of oxidant challenge, termed oxidative eustress, is essential for governing life processes through redox signaling. Recent interest has focused on the intricate ways by which redox signaling integrates these converse properties. Redox balance is maintained by prevention, interception, and repair, and concomitantly the regulatory potential of molecular thiol-driven master switches such as Nrf2/Keap1 or NF-κB/IκB is used for system-wide oxidative stress response. Nonradical species such as hydrogen peroxide (H 2 O 2 ) or singlet molecular oxygen, rather than free-radical species, perform major second messenger functions. Chemokine-controlled NADPH oxidases and metabolically controlled mitochondrial sources of H 2 O 2 as well as glutathione- and thioredoxin-related pathways, with powerful enzymatic back-up systems, are responsible for fine-tuning physiological redox signaling. This makes for a rich research field spanning from biochemistry and cell biology into nutritional sciences, environmental medicine, and molecular knowledge-based redox medicine.

Citations

• Role of Oxidative Modifications in Atherosclerosis
• Free radicals, reactive oxygen species, oxidative stress and its classification
• Hydroperoxide metabolism in mammalian organs.
• Measuring oxidative damage to DNA and its repair with the comet assay
• Protein oxidation and peroxidation

Cited by

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• Early Signs of Inflammation With Mild Oxidative Stress in Mixed Martial Arts Athletes After Simulated Combat
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Discussions

• 2/3 Sies et al. (2017) map how millimolar glutathione maintains redox homeostasis and how its depletion shifts cancer cells toward oxidative damage. https://doi.org/10.1146/annurev-biochem-061516-0450 [bsky, 0 points, 1 comments]

Related

• Oxidative Stress
• Oxidative Stress: Concept and Some Practical Aspects
• Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
• Cellular Functional, Protective or Damaging Responses Associatedwith Different Redox Imbalance Intensities: A ComprehensiveReview
• Emerging Trends for the Regulation of Thiol-Based Redox Transcription Factor Pathways