2012/02/01 by Jean‐Charles Preiser · 234 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Nursing · #Antioxidant #Antioxidant Activity and Oxidative Stress #Biochemistry #Chemistry #Coenzyme Q10 studies and effects #Diabetes mellitus #Endocrinology #Internal medicine #Medicine #Mitochondrion #Oxidative damage #Oxidative phosphorylation #Oxidative stress #Pathological #Reactive oxygen species #Vitamin C and Antioxidants Research
paper · pdf · doi:10.1177/0148607111434963
published in Journal of Parenteral and Enteral Nutrition 36(2), 147-154 (Wiley)
openalex publication_date 2012/02/01 · openalex created_date 2022/05/12 · openalex updated_date 2026/07/29
Oxidative stress is defined by an imbalance between increased levels of reactive oxygen species (ROS) and a low activity of antioxidant mechanisms. An increased oxidative stress can induce damage to the cellular structure and potentially destroy tissues. However, ROS are needed for adequate cell function, including the production of energy by the mitochondria. Increased oxidative stress has been incriminated in physiological conditions, such as aging and exercise, and in several pathological conditions, including cancer, neurodegenerative diseases, cardiovascular diseases, diabetes, inflammatory diseases, and intoxications. However, prevention by antioxidants has been mostly inefficient. Therefore, a rigorous scientific evaluation in well-defined conditions is mandatory to define the appropriate place for manipulations of the oxidative pathways in human medicine.