The Dublin Lens: A Cc=1.0 mm Objective Lens Intended for CryoEM at 100 keV

2025/05/16 by Germano Motta Alves, Alves, Germano Motta, Theo Andrews +26 · 2 voices
Biochemistry, Genetics and Molecular Biology · Materials Science · Physics and Astronomy · #Advanced Electron Microscopy Techniques and Applications #Electron and X-Ray Spectroscopy Techniques #Advanced X-ray Imaging Techniques

paper · pdf · doi:10.48550/arxiv.2505.11458

Abstract

We have designed, fabricated and tested a lens with chromatic aberration coefficient (Cc) of 1.0 mm, a 4.0 mm pole-gap and 2.0 mm bore that is wide enough to accommodate an anti-contamination system and an objective aperture. This lens extends the temporal-coherence envelope of the electron microscope beyond 2 Angstrom, using a low-cost Schottky FEG. We hope that this lens design can be used to improve all 100 keV electron microscopes designed for single-particle electron cryomicroscopy (cryoEM).

Discussions

• At the 2024 IMC meeting, Richard Henderson laid down a challenge. Design a #TEM single-particle #cryoEM lens with 1mm Cc at 100kV. I'm thrilled to reveal our new Arxiv preprint delivering a fully retr [bsky, 21 points, 1 comments]
• arxiv.org/abs/2505.11458 [bsky, 0 points, 0 comments]

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