John Barnard
- The mutational constraint spectrum quantified from variation in 141,456 humans
2020/05/27 by Konrad J. Karczewski, Laurent C. Francioli, Grace Tiao +97 · 199 citations
Biochemistry, Genetics and Molecular Biology · #CRISPR and Genetic Engineering #Genomics and Phylogenetic Studies #Genomics and Rare Diseases
- Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
2021/02/10 by Daniel Taliun, Daniel Harris, Michael D. Kessler +97 · 60 citations
Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genomics and Rare Diseases #RNA Research and Splicing
- A genomic mutational constraint map using variation in 76,156 human genomes
2023/12/06 by Siwei Chen, Laurent C. Francioli, Julia K. Goodrich +254 · 71 citations
Biochemistry, Genetics and Molecular Biology · #Genomic variations and chromosomal abnormalities #Genomics and Chromatin Dynamics #Genomics and Rare Diseases
- Principal Stratification Approach to Broken Randomized Experiments
2003/06/01 by John Barnard, Constantine Frangakis, Jennifer Hill +1 · 9 citations
Mathematics · Social Sciences · #Advanced Causal Inference Techniques #School Choice and Performance #Urban, Neighborhood, and Segregation Studies
- Multi-ethnic genome-wide association study for atrial fibrillation
2018/06/08 by Carolina Roselli, Mark Chaffin, Lu‐Chen Weng +97 · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Genetic Associations and Epidemiology #Atrial Fibrillation Management and Outcomes #Cardiovascular Effects of Exercise
- Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data
2022/03/01 by Pierrick Wainschtein, Deepti Jain, Zhili Zheng +490 · 3 citations
Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genetic Mapping and Diversity in Plants and Animals #Genetic and phenotypic traits in livestock
- Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
2012/10/11 by Folkert W. Asselbergs, Yiran Guo, Erik P.A. van Iperen +97 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Genetic Associations and Epidemiology #Genetic and phenotypic traits in livestock #Lipid metabolism and disorders
- Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
2020/08/24 by Xihao Li, Zilin Li, Hufeng Zhou +450 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genomic variations and chromosomal abnormalities #Genomics and Rare Diseases
- A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies
2022/10/27 by Zilin Li, Xihao Li, Hufeng Zhou +531 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Genetic Associations and Epidemiology #Genomics and Rare Diseases
- Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies
2022/12/23 by Xihao Li, Corbin Quick, Hufeng Zhou +448 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Genetic Associations and Epidemiology #Genomics and Rare Diseases
- Gut microbial trimethylamine N-oxide generation promotes risk of atrial fibrillation via muscarinic receptor-mediated autonomic dysfunction
2026/07/24 by Selvam Arjunan, Isaiah Pemberton, Xinmin S. Li +25 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Atrial Fibrillation Management and Outcomes #Cardiac Health and Mental Health #Gut microbiota and health