Alessandro Aiuti

1. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
   2021/08/10 by Paul Bastard, Adrian Gervais, Tom Le Voyer +97 · 1 voice · 57 citations
   Medicine · Biochemistry, Genetics and Molecular Biology · #SARS-CoV-2 and COVID-19 Research #COVID-19 Clinical Research Studies #Diabetes and associated disorders
2. Autoantibodies against type I IFNs in patients with life-threatening COVID-19
   2020/09/24 by Paul Bastard, Lindsey B. Rosen, Qian Zhang +97 · 1 voice · 37 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #COVID-19 Clinical Research Studies #Diabetes and associated disorders #SARS-CoV-2 and COVID-19 Research
3. Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy
   2013/07/12 by Alessandra Biffi, Eugenio Montini, Laura Lorioli +34 · 6 citations
   Biochemistry, Genetics and Molecular Biology · #Virus-based gene therapy research #CRISPR and Genetic Engineering #RNA Interference and Gene Delivery
4. Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients
   2023/05/27 by Adrian Gervais, Francesca Rovida, Maria Antonietta Avanzini +59 · 1 voice · 11 citations
   Immunology and Microbiology · Medicine · #Complement system in diseases #Mosquito-borne diseases and control #Viral Infections and Vectors
5. The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
   2022/05/16 by Jérémy Manry, Paul Bastard, Adrian Gervais +97 · 1 voice · 6 citations
   Medicine · #COVID-19 Clinical Research Studies #Long-Term Effects of COVID-19 #SARS-CoV-2 and COVID-19 Research
6. A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity
   2024/12/16 by Fahd Al Qureshah, Jérémie Le Pen, Nicole A. de Weerd +91 · 3 voices · 8 citations
   Immunology and Microbiology · #interferon and immune responses #Immune Cell Function and Interaction #Immunodeficiency and Autoimmune Disorders
7. Update on gene therapy for adenosine deaminase-deficient severe combined immunodeficiency
   2010/10/28 by Francesca Ferrua, Immacolata Brigida, Alessandro Aiuti · 2 citations
   Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Virus-based gene therapy research #CRISPR and Genetic Engineering #Immunodeficiency and Autoimmune Disorders
8. Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome
   2013/07/12 by Alessandro Aiuti, Luca Biasco, Samantha Scaramuzza +37 · 3 citations
   Biochemistry, Genetics and Molecular Biology · #Virus-based gene therapy research #RNA Interference and Gene Delivery #CRISPR and Genetic Engineering
9. Gene therapy for ADA‐SCID, the first marketing approval of an ex vivo gene therapy in Europe: paving the road for the next generation of advanced therapy medicinal products
   2017/04/10 by Alessandro Aiuti, Maria Grazia Roncarolo, Luigi Naldini · 2 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Virus-based gene therapy research #CAR-T cell therapy research #Viral gastroenteritis research and epidemiology
10. Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C)
    2024/09/28 by Evangelos Bellos, David Santillo, Pierre Vantourout +95 · 2 voices · 1 citation
    Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Diabetes and associated disorders #Immune Cell Function and Interaction #Kawasaki Disease and Coronary Complications
11. Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations
    2021/04/23 by Julian Thalhammer, Gerhard Kindle, Alexandra Nieters +336 · 2 citations
    Immunology and Microbiology · Medicine · Health Professions · #Immunodeficiency and Autoimmune Disorders #Autoimmune and Inflammatory Disorders Research #Pediatric health and respiratory diseases
12. Inborn errors of immunity: Manifestation, treatment, and outcome—an ESID registry 1994–2024 report on 30,628 patients
    2025/07/17 by Gerhard Kindle, Mickaël Alligon, Michael H. Albert +97 · 1 voice · 2 citations
    Immunology and Microbiology · Medicine · #Cystic Fibrosis Research Advances #Immunodeficiency and Autoimmune Disorders #Parvovirus B19 Infection Studies
13. In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking
    2025/05/28 by Michela Milani, Anna Fabiano, Marta Perez-Rodriguez +26 · 1 voice · 1 citation
    Biochemistry, Genetics and Molecular Biology · #Pluripotent Stem Cells Research #Renal and related cancers #Virus-based gene therapy research