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Gonçalo R. Abecasis

  1. Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences
    2016/04/25 by G. David Poznik, G David Poznik, Yali Xue +56 · 52 citations
    Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Chromosomal and Genetic Variations #Forensic and Genetic Research #Genomic variations and chromosomal abnormalities
  2. A global reference for human genetic variation
    2015/09/29 by Corresponding authors, Adam Auton, Richard Durbin +90 · 71 citations
    Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genomics and Rare Diseases #Genomics and Phylogenetic Studies
  3. Rare-Variant Association Analysis: Study Designs and Statistical Tests
    2014/07/01 by Seunggeun Lee, Seunggeung Lee, Gonçalo R. Abecasis +3 · 46 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Computational biology #Computer science #Disease #Gene #Genetic Associations and Epidemiology #Genetic association #Genetics #Genetics and Neurodevelopmental Disorders #Genomics and Rare Diseases #Genotype #Genotyping #Heritability #Imputation (statistics) #Machine learning #Medicine #Missing data #Pathology #Population stratification #Single-nucleotide polymorphism #Trait
  4. Computationally efficient whole-genome regression for quantitative and binary traits
    2021/05/20 by Joelle Mbatchou, Leland Barnard, Joshua Backman +18 · 59 citations
    Biochemistry, Genetics and Molecular Biology · Mathematics · #Artificial intelligence #Biobank #Biology #Computational biology #Computer science #Contrast (vision) #Genetic Associations and Epidemiology #Genetic Mapping and Diversity in Plants and Animals #Genetic and phenotypic traits in livestock #Genetics #Genome #Genome-wide association study #Genotype #Machine learning #Mathematics #Population #Regression #Regression analysis #Statistics
  5. Low-Pass DNA Sequencing of 1200 Sardinians Reconstructs European Y-Chromosome Phylogeny
    2013/08/01 by Paolo Francalacci, Laura Morelli, Andrea Angius +36 · 18 citations
    Biochemistry, Genetics and Molecular Biology · Arts and Humanities · #Forensic and Genetic Research #Genetic diversity and population structure #Forensic Anthropology and Bioarchaeology Studies #Haplogroup #Phylogenetic tree #Evolutionary biology #Population #Biology #Mitochondrial DNA #Haplotype #DNA sequencing #Y chromosome #Genetics #Ancient DNA #Gene #Demography #Genotype
  6. Hundreds of variants clustered in genomic loci and biological pathways affect human height
    2010/09/29 by Hana Lango Allen, Karol Estrada, Guillaume Lettre +308 · 19 citations
    Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genetic Mapping and Diversity in Plants and Animals #Genetic and phenotypic traits in livestock
  7. NSK Software Technologies Ltd.
    1998/01/05 by Wenqing Fu, Timothy D. O’Connor, Goo Jun +13 · 6 citations
    Biochemistry, Genetics and Molecular Biology · Economics, Econometrics and Finance · #CRISPR and Genetic Engineering #Diverse Scientific and Economic Studies #Genomics and Phylogenetic Studies #Genomics and Rare Diseases
  8. Population Genomic Analysis of Ancient and Modern Genomes Yields New Insights into the Genetic Ancestry of the Tyrolean Iceman and the Genetic Structure of Europe
    2014/05/08 by Martin Sikora, Meredith L. Carpenter, Andrés Moreno‐Estrada +22 · 11 citations
    Biochemistry, Genetics and Molecular Biology · #Forensic and Genetic Research #Genetic diversity and population structure #Yersinia bacterium, plague, ectoparasites research #Haplogroup #Biology #Context (archaeology) #Genome #Evolutionary biology #Population #Ancient DNA #Genetics #Genetic variation #Genetic structure #Haplotype #Demography #Genotype #Gene #Paleontology
  9. Genome-wide association studies for complex traits: consensus, uncertainty and challenges
    2008/04/09 by Mark I. McCarthy, Gonçalo R. Abecasis, Lon R. Cardon +4 · 8 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · #Bioinformatics and Genomic Networks #Biology #Computational biology #Computer science #Data science #Disease #Evolutionary biology #Gene #Genetic Associations and Epidemiology #Genetic architecture #Genetic association #Genetics #Genome-wide association study #Genotype #Medicine #Molecular Biology Techniques and Applications #Phenotype #Single-nucleotide polymorphism
  10. Complex genetic signatures in immune cells underlie autoimmunity and inform therapy
    2020/09/14 by Valeria Orrù, Maristella Steri, Carlo Sidore +26 · 7 citations
    Immunology and Microbiology · Medicine · #Chronic Lymphocytic Leukemia Research #Immune Cell Function and Interaction #T-cell and B-cell Immunology
  11. Genomic history of the Sardinian population
    2018/09/07 by Charleston W. K. Chiang, Joseph H. Marcus, Joseph Marcus +17 · 7 citations
    Arts and Humanities · Biochemistry, Genetics and Molecular Biology · #Forensic Anthropology and Bioarchaeology Studies #Forensic and Genetic Research #Race, Genetics, and Society
  12. Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder
    2015/05/20 by Marleen H. M. de Moor, Stéphanie M. van den Berg, Karin J. H. Verweij +97 · 4 citations
    Biochemistry, Genetics and Molecular Biology · Psychology · Neuroscience · #Genetic Associations and Epidemiology #Personality Disorders and Psychopathology #Neurotransmitter Receptor Influence on Behavior
  13. Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data
    2022/03/01 by Pierrick Wainschtein, Deepti Jain, Zhili Zheng +490 · 3 citations
    Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genetic Mapping and Diversity in Plants and Animals #Genetic and phenotypic traits in livestock
  14. Evidence of association ofAPOEwith age-related macular degeneration - a pooled analysis of 15 studies
    2011/09/01 by Gareth J. McKay, Chris Patterson, Chris C. Patterson +56 · 1 citation
    Medicine · #Glaucoma and retinal disorders #Retinal Diseases and Treatments #Retinal Imaging and Analysis
  15. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
    2020/08/24 by Xihao Li, Zilin Li, Hufeng Zhou +450 · 2 citations
    Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genomic variations and chromosomal abnormalities #Genomics and Rare Diseases
  16. A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies
    2022/10/27 by Zilin Li, Xihao Li, Hufeng Zhou +531 · 2 citations
    Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Genetic Associations and Epidemiology #Genomics and Rare Diseases
  17. Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies
    2022/12/23 by Xihao Li, Corbin Quick, Hufeng Zhou +448 · 1 citation
    Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Genetic Associations and Epidemiology #Genomics and Rare Diseases
  18. Psoriasis Bench to Bedside
    2009/04/01 by Rajan P. Nair, Jun Ding, Kristina Callis Duffin +8 · 7 citations
    Immunology and Microbiology · Medicine · #Dermatology and Skin Diseases #Family medicine #Medicine #Medicine and Dermatology Studies History #Neurology #Otorhinolaryngology #Psoriasis: Treatment and Pathogenesis #Psychiatry