Terho Lehtimäki
- A genomic mutational constraint map using variation in 76,156 human genomes
2023/12/06 by Siwei Chen, Laurent C. Francioli, Julia K. Goodrich +254 · 62 citations
Biochemistry, Genetics and Molecular Biology · #Genomic variations and chromosomal abnormalities #Genomics and Chromatin Dynamics #Genomics and Rare Diseases
- Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
2020/01/23 by F. Kyle Satterstrom, Jack A. Kosmicki, Jiebiao Wang +97 · 33 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Autism Spectrum Disorder Research #Congenital heart defects research #Genetics and Neurodevelopmental Disorders
- Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
2021/09/01 by Urmo Võsa, Annique Claringbould, Harm-Jan Westra +124 · 27 citations
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Genetic Associations and Epidemiology #Single-cell and spatial transcriptomics
- MicroRNAs in the Atherosclerotic Plaque
2013/06/01 by Emma Raitoharju, Niku Oksala, Terho Lehtimäki · 27 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Immunology and Microbiology · #MicroRNA in disease regulation #Nuclear Receptors and Signaling #Atherosclerosis and Cardiovascular Diseases
- Rare coding variation provides insight into the genetic architecture and phenotypic context of autism
2022/08/18 by Jack M. Fu, Jack Fu, F. Kyle Satterstrom +136 · 8 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Autism Spectrum Disorder Research #Congenital heart defects research #Genomic variations and chromosomal abnormalities
- Genome-wide analysis identifies novel susceptibility loci for myocardial infarction
2020/12/08 by Jaana Hartiala, Jaana A Hartiala, Yi Han +87 · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Folate and B Vitamins Research #Genetic Associations and Epidemiology #Peroxisome Proliferator-Activated Receptors
- Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals
2019/03/14 by Pooja R Mandaviya, Pooja R. Mandaviya, Roby Joehanes +76 · 25 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Folate and B Vitamins Research #Epigenetics and DNA Methylation #Nutrition, Genetics, and Disease
- Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
2018/11/01 by Symen Ligthart, Ahmad Vaez, Urmo Võsa +341 · 25 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Health Professions · #Genetic Associations and Epidemiology #IL-33, ST2, and ILC Pathways #Adolescent and Pediatric Healthcare