2025/04/03 by Beata Kruk, Joanna Raszeja‐Wyszomirska, Marcin Krawczyk +1
Medicine · #Cancer Immunotherapy and Biomarkers #Genetic factors in colorectal cancer #Internal medicine #Liver Diseases and Immunity #Medicine #Prospective cohort study
paper · doi:10.1111/eci.70041
openalex publication_date 2025/04/03 · openalex created_date 2025/04/04 · openalex updated_date 2026/08/05
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are rare liver diseases that significantly impair quality of life (QoL). In this study, we analysed two large cohorts comprising a total of 1267 patients with PBC and PSC, showing that fatigue is a frequent symptom in both conditions, particularly among females. Fatigue was associated with liver function markers (ALP/GGT in PSC) and with cirrhosis (in PBC). It was also often linked to cholestatic pruritus, further compromising QoL. The authors declare no commercial or non-commercial conflict of interest. Data from patients who have consented to share their data with other investigators are available upon request from the corresponding author.