2018/06/06 by Roland Immler, Scott I. Simon, Markus Sperandio · 2 citations
Immunology and Microbiology · Neuroscience · Biochemistry, Genetics and Molecular Biology · #Neutrophil, Myeloperoxidase and Oxidative Mechanisms #Ion Channels and Receptors #Calcium signaling and nucleotide metabolism
paper · pdf · doi:10.1111/eci.12964
Abstract The recruitment of neutrophils to sites of inflammation, their battle against invading microorganisms through phagocytosis and the release of antimicrobial agents is a highly coordinated and tightly regulated process that involves the interplay of many different receptors, ion channels and signalling pathways. Changes in intracellular calcium levels, caused by cytosolic Ca 2+ store depletion and the influx of extracellular Ca 2+ via ion channels, play a critical role in synchronizing neutrophil activation and function. In this review, we provide an overview of how Ca 2+ signalling is initiated in neutrophils and how changes in intracellular Ca 2+ levels modulate neutrophil function.