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Unfolding the Genome

2022/04/18 by Ranganathan, Gupi, Lieberman Aiden, Erez, Aiden Lab
#Applied Math #Art &amp #Art as Research #Biology #Genomic Research #Science Collaboration

paper · doi:10.48807/2021.0086

Abstract

From 2009-2011, we worked together at the Broad Institute of MIT and Harvard (Broad Institute, n.d.), building on a study (Lieberman-Aiden & Van Berkum et al., 2009) that made it possible to explore how the human genome, the DNA contained in every cell of the body, folds in 3D. At the outset of our collaboration, our approaches seemed so different as to be, perhaps, incommensurable. The scientists used tools like mathematics, computer science, and molecular biology, whereas the artistic toolkit was focused on the construction of physical objects, with a defined shape, area, and volume. Yet over time, we came to realize that all of these tools were addressing the same goal: making invisible concepts manifest as an experience intelligible to the senses. From the beginning of the project, we worked together creating drawings. Over time, our interactions evolved to become free-flowing conversations while drawing, which became a way of seeing together. Our visual experimentations grew into a body of drawings, paintings, prints, mixed-media artworks, wood blocks, a dynamic video installation, and a suspended wire sculpture (Ranganathan, 2021), and helped advance the scientific community’s understanding of how the human genome folds. Keywords: Art & Science Collaboration, Art as Research, Art, Genomic Research, Applied Math, Biology

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