2025/01/03 by Paolo Cravedi, Umberto Maggiore, Paolo Molinari +2 · 4 citations
Medicine · #Chronic disease #Clinical trial #Intensive care medicine #Medicine #Organ Transplantation Techniques and Outcomes #Pathology #Renal Transplantation Outcomes and Treatments #Transplantation: Methods and Outcomes
paper · open access · doi:10.1097/tp.0000000000005081
published in Transplantation 109(3), 411-417 (Wolters Kluwer)
openalex publication_date 2025/01/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06
Chronic rejection is arguably the main obstacle to long-term graft survival. Yet, clinical trials focusing on this condition are disappointingly scarce. Significant advances in treating chronic rejection cannot happen if there is no conduit for testing novel therapies. Here, we identified the main hurdles holding back clinical trials for chronic rejection and outlined a series of actions to address these roadblocks. We suggest that a new strategic plan combining expertise in basic and clinical research and leveraging complementary resources be launched to specifically target chronic rejection and achieve long-awaited progress. We only need the will.