2011/11/01 by Line Clemmensen, Line Katrine Harder Clemmensen, Trevor Hastie +3 · 554 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Computer Science · Mathematics · #Artificial intelligence #Computer science #Discriminant #Face and Expression Recognition #Gene expression and cancer classification #Linear discriminant analysis #Mathematics #Multiple discriminant analysis #Optimal discriminant analysis #Pattern recognition (psychology) #Spectroscopy and Chemometric Analyses #Statistics
paper · doi:10.1198/tech.2011.08118
published in Technometrics 53(4), 406-413 (Taylor & Francis)
openalex publication_date 2011/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
We consider the problem of performing interpretable classification in the high-dimensional setting, in which the number of features is very large and the number of observations is limited. This setting has been studied extensively in the chemometrics literature, and more recently has become commonplace in biological and medical applications. In this setting, a traditional approach involves performing feature selection before classification. We propose sparse discriminant analysis, a method for performing linear discriminant analysis with a sparseness criterion imposed such that classification and feature selection are performed simultaneously. Sparse discriminant analysis is based on the optimal scoring interpretation of linear discriminant analysis, and can be extended to perform sparse discrimination via mixtures of Gaussians if boundaries between classes are nonlinear or if subgroups are present within each class. Our proposal also provides low-dimensional views of the discriminative directions.