2024/03/19 by Sanjeevagol, Shaila, Manjanna, Jayappa, Rudrappa, Chaithra
#COVID-19 #Favipiravir #G/In2O3 nanocatalyst #Modified pencil graphite electrode #Voltammetry
paper · doi:10.57647/j.ijc.2024.1401.03
Favipiravir (FVP) was one of the promising medications for the treatment of Covid-19 patients. There are limited studies on the electrochemical performance of FVP. Hence it is interesting to study the electrochemical detection of FVP by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry. The G/In2O3 nanocatalyst was prepared by precipitation method and applied on the pencil graphite electrode by drop-cast method, the electrode represented here as G/In2O3/MPGE and used as a working electrode for the detection of FVP in a pH 7 Britton Robinson (BR) buffer. The oxidation signal was seen in the region of 1.0 to 1.23 V. The predicted linear range is between 0.7 to 4.9 μM. The corresponding limit of detection (LOD) and limit of quantification (LOQ) were found for pure drugs at 0.28 μM and 0.93 μM, whereas for samples in commercial tablets, it is 0.23 and 0.79 μM. The same in the presence of urine medium is 0.30 and 106 μM, respectively. The developed G/In2O3/MPGE offers good detection, selectivity, reasonable stability, and reproducibility to detect FVP in pure drug, tablet form, and in the presence of urine. Highlights: The G/In2O3 was prepared successfully and applied on the pencil graphite by drop-cast method for the detection of favipiravir (FVP). The RCT of the G/In2O3/MPGE is 147.6 W and conductivity is 1.35 x 10–3 S cm–1. The LOD was 0.28, 0.23 and 0.30 mM for pure, tablet and in presence of urine, respectively. Also, G/In2O3/MPGE showed good response even in the presence of other co-administered drugs such as HCQ, paracetamol, and acivir as well as folic acid and ascorbic acid. The G/In2O3/MPGE fabricated here is stable up to 30 days with a marginal decrease in current