2015/07/09 by Yoshiyasu Ichikawa, Rika Mimura, Ayumi Kitamori +4
Biochemistry, Genetics and Molecular Biology · Medicine · Chemistry · #Marine Sponges and Natural Products #Microbial Natural Products and Biosynthesis #Synthetic Organic Chemistry Methods
paper · doi:10.1055/s-0034-1380438
One-pot syntheses of models of the right-hand portion and the central part of the respective structures of halichonadins Q and M, using the Ugi five-center four-component reaction (U-5C-4CR), were executed. The biomimetic strategy employed in these routes demonstrates the feasibility of pathways we have proposed for the biosynthesis of marine organisms.