An Approach to Botrydianes: On the Steric Demands of a Metal Catalyzed Enyne Metathesis

1993/01/01 by Barry M. Trost, Virginia K. Chang · 85 citations
Chemistry · #Catalysis #Catalytic Alkyne Reactions #Chemistry #Combinatorial chemistry #Enyne #Enyne metathesis #Metathesis #Organic chemistry #Organometallic Complex Synthesis and Catalysis #Palladium #Platinum #Salt metathesis reaction #Steric effects #Synthetic Organic Chemistry Methods #Transition metal

paper · doi:10.1055/s-1993-25950

published in Synthesis 1993(08), 824-832 (Thieme Medical Publishers (Germany))

openalex publication_date 1993/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

All articles of this category The synthetic scope of a transition metal catalyzed enyne metathesis as a synthesis of 1-alkenylcycloalkenes is tested. Contrary to normal expectations based upon the important sensitivity of transition metal catalyzed reactions to steric effects, severe steric congestion enhances the effectiveness of the reaction. While palladium based catalysts are generally preferred, a platinum catalyst also effects these novel cyclorearrangements.

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• Transition Metal Catalyzed Cycloisomerizations of 1,n-Allenynes and -Allenenes
• Application of Pauson-Khand reaction in the total synthesis of terpenes. [europepmc]

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