Palladium-Catalyzed Reaction of Arylboronic Acids with Aliphatic Nitriles: Synthesis of Alkyl Aryl Ketones and 2-Arylbenzofurans

2013/06/11 by Miaochang Liu, Jiuxi Chen, Xingyong Wang +3
Chemistry · #Catalytic C–H Functionalization Methods #Cyclopropane Reaction Mechanisms #Catalytic Cross-Coupling Reactions

paper · doi:10.1055/s-0033-1338909

Abstract

An efficient palladium-catalyzed addition of arylboronic acids to aliphatic nitriles has been developed, providing a wide range of alkyl aryl ketones in moderate to excellent yields. It is noteworthy that sequential addition and intramolecular annulation reaction of 2-(2-hydroxyphenyl)acetonitriles with arylboronic acids are also conducted smoothly to afford 2-arylbenzofurans in good yields under the standard conditions.

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