Chiral Phosphoric Acids as Versatile Catalysts for Enantioselective Transformations

2010/05/27 by Masahiro Terada · 1,271 citations
Chemistry · #Asymmetric Synthesis and Catalysis #Asymmetric carbon #Axial and Atropisomeric Chirality Synthesis #Brønsted–Lowry acid–base theory #Catalysis #Chemistry #Combinatorial chemistry #Enantioselective synthesis #Heteroatom #Molecular spectroscopy and chirality #Optically active #Organic chemistry #Organocatalysis #Phosphoric acid #Ring (chemistry)

paper · doi:10.1055/s-0029-1218801

published in Synthesis 2010(12), 1929-1982 (Thieme Medical Publishers (Germany))

openalex publication_date 2010/05/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Chiral phosphoric acids derived from axially chiral biaryls and related chiral Brønsted acids have emerged as an attractive and widely applicable class of enantioselective organocatalysts for a variety of organic transformations. This review focuses on recent achievements in the development of enantioselective transformations using these axially chiral phosphoric acids and their analogues as chiral Brønsted acid catalysts. The contents are arranged according to the specific types of carbon-carbon bond-forming reactions, followed by carbon-heteroatom bond-forming reactions and functional group transformations, including reduction and oxidation. Further applications to combined phosphoric acid and metal complex catalytic systems and new aspects in the development of chiral Brønsted acid catalysts are also highlighted.

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