An Efficient Synthesis of 1,3-Benzothiadiazin-4(3H)-one 2-Oxides: Novel Anthranilic Acid Derivatives

2016/06/15 by Sitaram Pal, Indira Sen, Swarnendu Sasmal +1
Chemistry · Biochemistry, Genetics and Molecular Biology · #Quinazolinone synthesis and applications #Phenothiazines and Benzothiazines Synthesis and Activities #Synthesis and Catalytic Reactions

paper · doi:10.1055/s-0035-1561657

Abstract

Derivatives of anthranilic acid exhibit a range of useful biological activities. Herein we describe an efficient synthetic route to 1,3-benzothiadiazin-4(3<i>H</i>)-one 2-oxides via copper-catalyzed N-arylation of sulfonimidamides followed by cyclization. Such 1,3-benzothiadiazin-4(3<i>H</i>)-one 2-oxides can be viewed as novel anthranilic acid derivatives.

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