2017/02/11 by Daniel Miller, Miller, Daniel
Biochemistry, Genetics and Molecular Biology · Medicine · #Computation and Language (cs.CL) #FOS: Computer and information sciences #Heart Failure Treatment and Management #Pharmaceutical studies and practices #Receptor Mechanisms and Signaling
paper · pdf · doi:10.48550/arxiv.1702.04615
openalex publication_date 2017/02/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Congestive Heart Failure, or CHF, is a serious medical condition that can result in fluid buildup in the body as a result of a weak heart. When the heart can't pump enough blood to efficiently deliver nutrients and oxygen to the body, kidney function may be impaired, resulting in fluid retention. CHF patients require a broad drug regimen to maintain the delicate system balance, particularly between their heart and kidneys. These drugs include ACE inhibitors and Beta Blockers to control blood pressure, anticoagulants to prevent blood clots, and diuretics to reduce fluid overload. Many of these drugs may interact, and potential effects of these interactions must be weighed against their benefits. For this project, we consider a set of 44 drugs identified as specifically relevant for treating CHF by pediatric cardiologists at Lucile Packard Children's Hospital. This list was generated as part of our current work at the LPCH Heart Center. The goal of this project is to identify and evaluate potentially harmful drug-drug interactions (DDIs) within pediatric patients with Congestive Heart Failure. This identification will be done autonomously, so that it may continuously update by evaluating newly published literature.