2015/03/05 by Minghua Song, Song, Minghua, Yunxin Zhang +1
Biochemistry, Genetics and Molecular Biology · Earth and Planetary Sciences · Mathematics · #Asymmetric simple exclusion process #Biological system #Biology #Boundary (topology) #Boundary value problem #Classical mechanics #Computer science #Domain (mathematical analysis) #Earth Systems and Cosmic Evolution #Ecology #FOS: Biological sciences #Magnetosphere particle motion #Materials science #Mathematical analysis #Mathematics #Microtubule and mitosis dynamics #Molecular motor #Motion (physics) #Nanotechnology #Particle (ecology) #Particle density #Physics #Quantum mechanics #Statistical physics #Stochastic processes and statistical mechanics #Subcellular Processes (q-bio.SC) #Track (disk drive) #q-bio.SC
paper · pdf · doi:10.48550/arxiv.1503.01555
published in arXiv (Cornell University) (Cornell University)
arxiv created 2015/03/05 · openalex publication_date 2015/03/05 · arxiv updated 2015/03/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
In cells, most of cargos are transported by motor proteins along microtubule. Biophysically, unidirectional motion of large number of motor proteins along a single track can be described by totally asymmetric simple exclusion process (TASEP). From which many meaningful properties, such as the appearance of domain wall (defined as the borderline of high density and low density of motor protein along motion track) and boundary layers, can be obtained. However, it is biologically obvious that a single track may be occupied by different motor species. So previous studies based on TASEP of one particle species are not reasonable enough to find more detailed properties of the motion of motors along a single track. To address this problem, TASEP with two particle species is discussed in this study. Theoretical methods to get densities of each particle species are provided. Using these methods, phase transition related properties of particle densities are obtained. Our analysis show that domain wall and boundary layer of single species densities always appear simultaneously with those of the total particle density. The height of domain wall of total particle density is equal to the summation of those of single species. Phase diagrams for typical model parameters are also presented. The methods presented in this study can be generalized to analyze TASEP with more particle species.