2013/08/09 by Dagmar Iber, Iber, Dagmar, Denis Menshykau +1
Biochemistry, Genetics and Molecular Biology · #FOS: Biological sciences #Molecular Networks (q-bio.MN) #Tissues and Organs (q-bio.TO) #q-bio.MN #q-bio.TO
paper · pdf · doi:10.48550/arxiv.1308.2123
The Control of Branching Morphogenesis
arxiv created 2013/08/09 · arxiv updated 2013/08/12
Many organs of higher organisms are heavily branched structures and arise by an at first sight similar process of branching morphogenesis. Yet the regulatory components and local interactions that have been identified differ greatly in these organs. It is an open question whether the regulatory processes work according to a common principle and in how far physical and geometric constraints determine the branching process. Here we review the known regulatory factors and physical constraints in lung, kidney, pancreas, prostate, mammary and salivary gland branching morphogenesis, and describe the models that have been formulated to analyse their impacts.