2024/06/10 by Geongyu Lee, Joonho Lee, Lee, Geongyu +12
Computer Science · Engineering · Medicine · #AI in cancer detection #Computer Vision and Pattern Recognition (cs.CV) #FOS: Computer and information sciences #FOS: Electrical engineering #Image and Video Processing (eess.IV) #Radiomics and Machine Learning in Medical Imaging #cs.CV #eess.IV #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.2406.06650
published as Scientific Reports 15, 35069 (2025) · 20 pages, 9 figures
openalex publication_date 2024/06/10 · openalex created_date 2024/06/13 · arxiv created 2025/04/09 · openalex updated_date 2026/07/30 · arxiv updated 2026/08/05
Accurate prediction of the likelihood of recurrence is important in the selection of postoperative treatment for patients with early-stage breast cancer. In this study, we investigated whether deep learning algorithms can predict patients' risk of recurrence by analyzing the pathology images of their cancer histology.We analyzed 125 hematoxylin and eosin-stained whole slide images (WSIs) from 125 patients across two institutions (National Cancer Center and Korea University Medical Center Guro Hospital) to predict breast cancer recurrence risk using deep learning. Sensitivity reached 0.857, 0.746, and 0.529 for low, intermediate, and high-risk categories, respectively, with specificity of 0.816, 0.803, and 0.972, and a Pearson correlation of 0.61 with histological grade. Class activation maps highlighted features like tubule formation and mitotic rate, suggesting a cost-effective approach to risk stratification, pending broader validation. These findings suggest that deep learning models trained exclusively on hematoxylin and eosin stained whole slide images can approximate genomic assay results, offering a cost-effective and scalable tool for breast cancer recurrence risk assessment. However, further validation using larger and more balanced datasets is needed to confirm the clinical applicability of our approach.