2017/04/06 by Matthias Gräser, Gräser, Matthias, Tobias Knopp +17
Biochemistry, Genetics and Molecular Biology · Engineering · Environmental Science · #Characterization and Applications of Magnetic Nanoparticles #FOS: Physical sciences #Geomagnetism and Paleomagnetism Studies #Medical Physics (physics.med-ph) #Minerals Flotation and Separation Techniques
paper · pdf · doi:10.48550/arxiv.1704.01789
openalex publication_date 2017/04/06 · openalex created_date 2022/10/05 · openalex updated_date 2026/07/28
Superparamagnetic iron-oxide nanoparticles can be used in a variety of\nmedical applications like vascular or targeted imaging. Magnetic particle\nimaging (MPI) is a promising tomographic imaging technique that allows\nvisualizing the 3D nanoparticle distribution concentration in a non-invasive\nmanner. The two main strengths of MPI are high temporal resolution and high\nsensitivity. While the first has been proven in the assessment of dynamic\nprocesses like cardiac imaging, it is unknown how far the detection limit of\nMPI can be lowered. Within this work, we will present a highly sensitive\ngradiometric receive-coil unit combined with a noise-matching network tailored\nfor the measurement of mice. The setup is capable of detecting 5 ng of iron in\nvitro at 2.14 sec acquisition time. In terms of iron concentration we are able\nto detect 156 \μg/L marking the lowest value that has been reported for an\nMPI scanner so far. In vivo MPI mouse images of a 512 ng bolus at 21.5 ms\nacquisition time allow for capturing the flow of an intravenously injected\ntracer through the heart of a mouse. Since it has been rather difficult to\ncompare detection limits across MPI publications we propose guidelines\nimproving the comparability of future MPI studies.\n