Dual-Energy Contrast-enhanced Digital Subtraction Mammography: Feasibility
2003/10/01 by John M. Lewin, John Lewin, Pamela K. Isaacs +2 · 385 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Artificial intelligence #Biopsy #Breast Cancer Treatment Studies #Breast cancer #Cancer #Computed tomography #Contrast (vision) #Digital Radiography and Breast Imaging #Digital mammography #Ductal carcinoma #Image (mathematics) #Image processing #Image subtraction #Internal medicine #Iodinated contrast #Mammography #Medical Imaging Techniques and Applications #Medicine #Nuclear medicine #Radiology #Subtraction
paper · doi:10.1148/radiol.2291021276
published in Radiology 229(1), 261-268 (Radiological Society of North America)
openalex publication_date 2003/10/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Abstract
A technique for demonstrating breast cancers, dual-energy contrast agent-enhanced digital subtraction mammography, was performed in 26 subjects with mammographic or clinical findings that warranted biopsy. The technique consists of high-energy and low-energy digital mammography after administration of iodinated contrast agent. Weighted subtraction of the logarithmic transform of these images is then performed to obtain an image that preferentially shows iodine. Of the 26 subjects, 13 had invasive cancers. Eleven of these tumors enhanced strongly, one enhanced moderately, and one enhanced weakly. The duct in one patient with ductal carcinoma in situ was weakly enhancing. In the other 12 patients, benign tissue enhanced diffusely in two and weakly focally in two. These results indicate that the technique is feasible and worthy of further study.
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