2014/09/11 by Sandip K. Datta, Datta, Sandip, Brian Seed +1
Biochemistry, Genetics and Molecular Biology · #Diffusion and Search Dynamics #FOS: Biological sciences #Fractal and DNA sequence analysis #Gene Regulatory Network Analysis #Subcellular Processes (q-bio.SC)
paper · pdf · doi:10.48550/arxiv.1409.3481
openalex publication_date 2014/09/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Recent experiments have shown that stochastic effects exerted at the level of\ntranslation contribute a substantial portion of the variation in abundance of\nproteins expressed at moderate to high levels. This study analyzes\ntranslational noise arising from fluctuations in residue-specific elongation\nrates. The resulting variation has multiplicative components that lead\nindividual protein abundances in a population to exhibit approximately\nlog-normal behavior. The high variability inherent in the process leads to\nparameter variation that has the features of a type of noise in biological\nsystems that has been characterized as extrinsic. Elongation rate variation\noffers an accounting for a major component of extrinsic noise, and the analysis\nprovided here highlights a probability distribution that is a natural extension\nof the Poisson and has broad applicability to many types of multiplicative\nnoise processes.\n