An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies
2011/05/31 by Peter C. Austin · 12,108 citations
Mathematics · #Advanced Causal Inference Techniques #Confounding #Covariate #Econometrics #Inverse probability weighting #Mathematics #Observational study #Propensity score matching #Statistical Methods and Bayesian Inference #Statistical Methods and Inference #Statistics
paper · pdf · doi:10.1080/00273171.2011.568786
published in Multivariate Behavioral Research 46(3), 399-424 (Taylor & Francis)
openalex publication_date 2011/05/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06
Abstract
The propensity score is the probability of treatment assignment conditional on observed baseline characteristics. The propensity score allows one to design and analyze an observational (nonrandomized) study so that it mimics some of the particular characteristics of a randomized controlled trial. In particular, the propensity score is a balancing score: conditional on the propensity score, the distribution of observed baseline covariates will be similar between treated and untreated subjects. I describe 4 different propensity score methods: matching on the propensity score, stratification on the propensity score, inverse probability of treatment weighting using the propensity score, and covariate adjustment using the propensity score. I describe balance diagnostics for examining whether the propensity score model has been adequately specified. Furthermore, I discuss differences between regression-based methods and propensity score-based methods for the analysis of observational data. I describe different causal average treatment effects and their relationship with propensity score analyses.
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- Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. [europepmc]
- The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement. [europepmc]
- The Propensity Score. [europepmc]
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- An introduction to inverse probability of treatment weighting in observational research. [europepmc]
- Long-term cardiovascular outcomes of COVID-19. [europepmc]
- Risks of mental health outcomes in people with covid-19: cohort study. [europepmc]
- Risks and burdens of incident diabetes in long COVID: a cohort study. [europepmc]
- Six-month sequelae of post-vaccination SARS-CoV-2 infection: A retrospective cohort study of 10,024 breakthrough infections. [europepmc]
- Postacute sequelae of COVID-19 at 2 years. [europepmc]
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