2025/11/01 by Teo, Kelvin Y C, Ponsioen, Theodorus Leonardus, Lan, Sioe +9
Medicine · #Retinal Diseases and Treatments #Ophthalmology and Visual Impairment Studies #Retinal Imaging and Analysis
paper · doi:10.5167/uzh-281176
Background: This study aimed to characterise visual acuity (VA) changes in eyes without baseline macular atrophy (MA) that subsequently developed MA during treatment for neovascular age-related macular degeneration (nAMD). Methods: A case-control analysis was performed using data from a multicentre real-world AMD registry. We compared VA outcomes in 1998 treatment-naïve eyes without MA at baseline and ≥ 5 years of follow-up. Two matched groups (999 eyes each) were analysed: eyes that developed incident MA and those that never did. Conclusion: It is important to achieve disease inactivity in nAMD despite its association with incident MA, as neovascular complications play a significant role in VA loss. The long duration between the incidence of MA and clinically significant loss of vision offers an opportunity for potential interventions against atrophy.