Achieving red-light anticancer photodynamic therapy under hypoxia using Ir( <scp>iii</scp> )–COUPY conjugates

2025/01/01 by Enrique Ortega, Anna Rovira, Pezhman Ashoo +14 · 4 voices
Engineering · Medicine · Biochemistry, Genetics and Molecular Biology · #Nanoplatforms for cancer theranostics #Photodynamic Therapy Research Studies #Cancer, Hypoxia, and Metabolism

paper · pdf · doi:10.1039/d4qi03369h

Abstract

Conjugation of COUPY dyes to cyclometalated Ir( iii ) complexes is a strategy at the frontier of the development of red-light-activated photosensitizers capable of operating under challenging hypoxic conditions, showing the promise of anticancer PDT.

Citations

• A guided tour into subcellular colocalization analysis in light microscopy
• A Threshold Selection Method from Gray-Level Histograms
• Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Discussions

• Happy to see our paper in print! We developed an iridium-coumarin platform that selectively induces oxidative cell death upon red light exposure, even in low-oxygen conditions! 🧪 Congrats to the team [bsky, 36 points, 1 comments]
• Nice to see our recent article on the Front cover- now published in Inorganic Chemistry Frontiers. doi.org/10.1039/D4QI.... Great collaboration with @MarchanLab_UB. [bsky, 12 points, 0 comments]
• Glad to see our last collaboration on Ir metal complexes for anticancer photodynamic therapy published in Inorg. Chem. Front.!!! @inorgchemfront.rsc.org doi.org/10.1039/D4QI... [bsky, 1 points, 0 comments]
• 📢Issue 09 of Inorganic Chemistry Frontiers is online! 👇Check out the outside front cover and the research behind the cover art——Achieving red-light #anticancer #photodynamic therapy under hypoxia u [bsky, 1 points, 0 comments]

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