The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics

2024/05/01 by Sook Wah Yee, Christian B. Macdonald, Darko Mitrovic +14 · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · #Drug Transport and Resistance Mechanisms #HIV/AIDS drug development and treatment #Amino Acid Enzymes and Metabolism

paper · pdf · doi:10.1016/j.molcel.2024.04.008

Citations

• Simple Allosteric Model for Membrane Pumps

Discussions

• The more I think about it, the more convinced I am that the holy grail here is if this can go beyond predicting ratio of folded to unfolded, to also predicting ratio of folded state A to folded states [bsky, 39 points, 4 comments]