Critical evaluation of stability constants of metal complexes of complexones for biomedical and environmental applications* (IUPAC Technical Report)

2005/01/01 by G. Anderegg, Giorgio Anderegg, Francoise Arnaud-Neu +4 · 302 citations
Chemical Engineering · Chemistry · Materials Science · #Chelation #Chemical Thermodynamics and Molecular Structure #Chemical and Physical Properties in Aqueous Solutions #Chemistry #Iminodiacetic acid #Inorganic chemistry #Ion #Lanthanide and Transition Metal Complexes #Metal #Nuclear chemistry #Organic chemistry #Stability constants of complexes

paper · pdf · doi:10.1351/pac200577081445

published in Pure and Applied Chemistry 77(8), 1445-1495 (International Union of Pure and Applied Chemistry)

openalex publication_date 2005/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25

Abstract

Abstract Available experimental data on stability constants of proton (hydron) and metal complexes for seven complexones of particular biomedical and environmental interest: iminodiacetic acid [2,2'-azanediyldiacetic acid, IDA], (methylimino)diacetic acid [2,2'-(methylazanediyl)diacetic acid, MIDA]; 2,2',2'',2'''-[(carboxymethyl)azanediyl]bis[(ethane-1,2-diyl)nitrilo]tetraacetic acid (DTPA), 3,6,9,12-tetrakis(carboxymethyl)-3,6,9,12-tetraazatetradecanedioic acid (TTHA); 2,2',2''-(1,4,7-triazonane-1,4,7-triyl)triacetic acid (NOTA); 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA); 2,2',2'',2'''-(1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetrayl)tetraacetic acid (TETA), published in 1945-2000, have been critically evaluated. Some typical errors in stability constant measurements for particular complexones are summarized. Higher quality data are selected and presented as “Recommended” or “Provisional”.

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