2021/03/27 by Shashank Acharya, Acharya, Shashank, Sourav Halder +9
Engineering · Medicine · #Bariatric Surgery and Outcomes #Elasticity and Material Modeling #FOS: Physical sciences #Fluid Dynamics (physics.flu-dyn) #Gastroesophageal reflux and treatments
paper · pdf · doi:10.48550/arxiv.2103.14814
openalex publication_date 2021/03/27 · openalex created_date 2022/07/25 · openalex updated_date 2026/07/28
Over the past few decades, in silico modeling of organ systems has\nsignificantly furthered our understanding of their physiology and biomechanical\nfunction. In this work, we present a detailed numerical model of the upper\ngastrointestinal (GI) tract that not only accounts for the fiber architecture\nof the muscle walls, but also the multiphasic components they help transport\nduring normal digestive function. Construction details for 3D models of\nrepresentative stomach geometry are presented along with a simple strategy for\nassigning circular and longitudinal muscle fiber orientations for each layer.\nBased on our previous work that created a fully resolved model of esophageal\nperistalsis, we extend the same principles to simulate gastric peristalsis by\nsystematically activating muscle fibers embedded in the stomach. Following\nthis, for the first time, we simulate gravity driven bolus emptying into the\nstomach due to density differences between ingested contents and fluid contents\nof the stomach. This detailed computational model of the upper gastrointestinal\ntract provides a foundation on which future models can be based that seek to\ninvestigate the biomechanics of acid reflux and probe various strategies for\ngastric bypass surgeries to address the growing problem of adult obesity.\n