Isolation of phomopsolide A as the antimycobacterial constituent of an unidentified endophyte of the Canadian medicinal plant Geum macrophyllum

2016/09/30 by Trina Mullin, Mullin, Trina, Trevor N. Clark +5
Medicine · Biochemistry, Genetics and Molecular Biology · #Microbial Natural Products and Biosynthesis #Plant Pathogens and Fungal Diseases #Fungal Biology and Applications

paper · doi:10.14288/cjur.v2i1.188630

Abstract

An extract of an unidentified green filamentous fungus isolated as an endophyte of the Canadian medicinal plant Geum macrophyllum exhibited significant antimycobacterial activity and a distinct 1H NMR profile. Bioassay guided fractionation indicated that the natural product phomopsolide A (1) was responsible for the distinguishing characteristics of the extract.

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