Growth hormone and its disorders

2006/01/01 by J Ayuk, John Ayuk, M C Sheppard +1 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Growth Hormone and Insulin-like Growth Factors #Pituitary Gland Disorders and Treatments #Genetic Syndromes and Imprinting

paper · doi:10.1136/pgmj.2005.036087

Abstract

Growth hormone (GH) is synthesised and secreted by the somatotroph cells of the anterior lobe of the pituitary gland. Its actions involve multiple organs and systems, affecting postnatal longitudinal growth as well as protein, lipid, and carbohydrate metabolism. GH hypersecretion results in gigantism or acromegaly, a condition associated with significant morbidity and mortality, while GH deficiency results in growth retardation in children and the GH deficiency syndrome in adults. This article, aimed at non-paediatric physicians, examines the clinical features, diagnosis, and current concepts in the management of these conditions.

Citations

• Consensus Guidelines for the Diagnosis and Treatment of Adults with Growth Hormone Deficiency: Summary Statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency 1

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• Polymorphism of growth hormone (GH) gene and its association with performance and body conformation of Harnali sheep

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