2006/08/01 by A Thwaini, Ali Thwaini, Asad Khan +11 · 28 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Antimicrobial Resistance in Staphylococcus #Bacterial Identification and Susceptibility Testing #Debridement (dental) #Dermatology #Disease #Fasciitis #Fournier gangrene #Gangrene #Genitourinary system #Intensive care medicine #Internal medicine #Medicine #Sepsis #Streptococcal Infections and Treatments #Surgery
paper · pdf · doi:10.1136/pgmj.2005.042069
openalex publication_date 2006/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04
Fournier's gangrene (FG) is a rare but life threatening disease. Although originally thought to be an idiopathic process, FG has been shown to have a predilection for patients with diabetes as well as long term alcohol misuse; however, it can also affect patients with non-obvious immune compromise. The nidus is usually located in the genitourinary tract, lower gastrointestinal tract, or skin. FG is a mixed infection caused by both aerobic and anaerobic bacterial flora. The development and progression of the gangrene is often fulminating and can rapidly cause multiple organ failure and death. Because of potential complications, it is important to diagnose the disease process as early as possible Although antibiotics and aggressive debridement have been broadly accepted as the standard treatment, the death rate remains high.