Fatal Stevens-Johnson syndrome following urography with iopamidol in systemic lupus erythematosus

1988/05/01 by John Savill, J S Savill, Rosemary Barrie +9
Medicine · #Coagulation, Bradykinin, Polyphosphates, and Angioedema #Drug-Induced Adverse Reactions #Urticaria and Related Conditions

paper · pdf · doi:10.1136/pgmj.64.751.392

Abstract

A 46 year old white woman with active systemic lupus erythematosus developed a skin rash 8 hours after intravenous urography with the non-ionic contrast medium iopamidol. Severe Stevens-Johnson syndrome with erythema multiforme, intrahepatic cholestasis, pulmonary infiltrates and acute renal failure ensued, leading to her death. Although non-ionic contrast media are generally less toxic than traditional ionic agents, their use in patients with immunological disease may be hazardous.

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