Adenotonsillar microbiome: an update
2018/06/08 by James Jordan Johnston, James Johnston, Richard Douglas · 25 citations
Biochemistry, Genetics and Molecular Biology · Dentistry · Medicine · #Bioinformatics #Biology #Computational biology #Computer science #Data science #Genomics and Phylogenetic Studies #Gut microbiota and health #Medicine #Microbiome #Oral microbiology and periodontitis research
paper · doi:10.1136/postgradmedj-2018-135602
openalex publication_date 2018/06/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
Abstract
Pathogenic bacteria associated with the adenoids and tonsils cause much morbidity in the paediatric population. Hyperplasia of the adenoids is associated with otitis media with effusion and hyperplasia of the palatine tonsils is associated with both recurrent tonsillitis and obstructive sleep apnoea. Most current knowledge of the microbiology of the upper airways has been derived from culture-based studies, which usually reflect only a small fraction of the bacteria present on the mucosal surface. Culture-independent molecular surveys based on 16S ribosomal RNA sequencing are now being employed to determine the microbiota on the surface and within the tissue of adenoids and palatine tonsils. This review describes the new techniques applied in determining the microbiome and summarises the results of studies employing these techniques.
Citations
Cited by
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