Keloids and Hypertrophic Scars

1989/11/01 by W. Bradford Rockwell, I. Kelman Cohen, H. Paul Ehrlich · 25 citations
Medicine · #Dermatologic Treatments and Research #Body Contouring and Surgery #Wound Healing and Treatments

paper · doi:10.1097/00006534-198911000-00021

Abstract

A keloid results when a healing skin injury produces excess connective tissue that extends beyond the confines of the original wound1 and which tends to recur after excision. Keloids were first described centuries ago in the Smith papyrus, later in 1770 by Retz, and in 1802 by Alibert, 2–4 who proposed the current name. Their exact etiology and nature are not known,5 and a universally effective treatment has not been found. Developments in wound healing and collagen metabolism have provided insight and direction to the process, but better understanding of its biochemistry and cellular physiology is necessary before improved treatment can be found.

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• Review of the female Duroc/Yorkshire pig model of human fibroproliferative scarring. [europepmc]
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• Upregulation of microRNA-205 suppresses vascular endothelial growth factor expression-mediated PI3K/Akt signaling transduction in human keloid fibroblasts. [europepmc]
• Honokiol Alleviates Hypertrophic Scar by Targeting Transforming Growth Factor-β/Smad2/3 Signaling Pathway. [europepmc]
• Intralesional Injection of Botulinum Toxin Type A Compared with Intralesional Injection of Corticosteroid for the Treatment of Hypertrophic Scar and Keloid: A Systematic Review and Meta-Analysis. [europepmc]
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• In Vitro and Ex Vivo Models for Functional Testing of Therapeutic Anti-scarring Drug Targets in Keloids. [europepmc]
• Hypertrophic scars and keloids: Overview of the evidence and practical guide for differentiating between these abnormal scars. [europepmc]
• The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models. [europepmc]
• The use of botulinum toxin in keloid scar management: a literature review. [europepmc]
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• Current Advances in Hypertrophic Scar and Keloid Management. [europepmc]
• Arginase Signalling as a Key Player in Chronic Wound Pathophysiology and Healing. [europepmc]
• Use of Adipose Stem Cells Against Hypertrophic Scarring or Keloid. [europepmc]
• Perioperative interstitial high-dose-rate brachytherapy for keloids scar. [europepmc]

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