2025/11/12 by Hanifi, Safa, Shirini, Farhad, Ramezanzadeh, Bahram +1
#Heterogeneous catalyst #MXene #Nanocomposite #PMO #Periodic mesoporous organosillica #Pyrazole #Ti3AlC2
paper · doi:10.57647/jnsc.2025.1505.19
In this study, we report the development of a novel and efficient MXene-based heterogeneous catalyst, PMO@MXene, for the green synthesis of 5-amino-3-(aryl)-1-phenyl-1H-pyrazole-4-carbonitrile derivatives. By integrating periodic mesoporous organosilica (PMO) into multilayered MXene, a hybrid nanocomposite was achieved that benefits from the high surface area and electrical conductivity of MXene along with the welldefined mesoporosity of PMO. This unique synergy enabled highly efficient catalytic performance under mild, eco-friendly conditions, requiring only a small amount of catalyst and allowing for easy recovery and reuse with minimal loss of activity. The pyrazole derivatives, known for their potential pharmaceutical relevance, were obtained in excellent yields and characterized using standard spectroscopic techniques. Importantly, this work highlights the potential of the PMO@MXene as a sustainable and recyclable heterogeneous catalyst platform for the synthesis of biologically significant heterocyclic compounds.