A cytochrome P450 monooxygenase responsible for the C-22 hydroxylation step in the Paris polyphylla steroidal saponin biosynthesis pathway

2018/09/27 by Yan Yin, Linhui Gao, Xianan Zhang +1 · 16 citations
Biochemistry, Genetics and Molecular Biology · #Phytochemical Studies and Bioactivities #Natural product bioactivities and synthesis #Plant biochemistry and biosynthesis

paper · doi:10.1016/j.phytochem.2018.09.005

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• Rational design strategies for functional reconstitution of plant cytochrome P450s in microbial systems. [europepmc]
• Effective prediction of biosynthetic pathway genes involved in bioactive polyphyllins in Paris polyphylla. [europepmc]
• Genome sequencing of Inonotus obliquus reveals insights into candidate genes involved in secondary metabolite biosynthesis. [europepmc]
• RNA-Seq analysis reveals the important co-expressed genes associated with polyphyllin biosynthesis during the developmental stages of Paris polyphylla. [europepmc]
• Molecular cloning, functional characterization and expression of the β-amyrin synthase gene involved in saikosaponin biosynthesis in Bupleurum chinense DC. [europepmc]
• Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants. [europepmc]
• Endophyte-inoculated rhizomes of Paris polyphylla improve polyphyllin biosynthesis and yield: a transcriptomic analysis of the underlying mechanism. [europepmc]
• Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast. [europepmc]
• Genomic insights into Aspergillus tamarii TPD11: enhancing polyphyllin production and uncovering potential therapeutic applications. [europepmc]
• Understory growth of Paris polyphylla accumulates a reservoir of secondary metabolites of plants. [europepmc]
• Elucidation of the biosynthetic pathways of timosaponins reveals the antifungal mechanisms in Anemarrhena asphodeloides. [europepmc]
• The biosynthesis of trillin 6'- O -glucoside: A low-abundance yet pharmacologically active polyphyllin from Paris polyphylla . [europepmc]
• Advancements in Crop PUFAs Biosynthesis and Genetic Engineering: A Systematic and Mixed Review System. [europepmc]
• The clarification of two hydroxylation steps in the conversion of cholesterol to OSW-1 in Ornithogalum saundersiae. [europepmc]
• Identification and engineering of a UDP-rhamnosyltransferase from Trillium tschonoskii for heterologous biosynthesis of polyphyllin Ⅱ in yeast. [europepmc]