2025/06/02 by Sylvain Maclot, T. Reinert, Maclot, S. +29
Chemistry · Engineering · #Biological Physics (physics.bio-ph) #Biosensors and Analytical Detection #Chemical Physics (physics.chem-ph) #FOS: Physical sciences #Instrumentation and Detectors (physics.ins-det) #Ion-surface interactions and analysis #Mass Spectrometry Techniques and Applications
paper · pdf · doi:10.48550/arxiv.2506.01593
openalex publication_date 2025/06/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
This work presents the implementation of a new charge detection mass spectrometer (CDMS) design that operates in a stand-alone mode, thanks to its integration with nanoelectrospray ionization. More specifically, this innovative CDMS consists of a linear charge detection array ion trap spectrometer that combines an eight-tube detector array with conical electrodes. This configuration allows for recording data in both transmission mode (linear array) and ion trapping mode (ConeArrayTrap), which enables the measurement of time-of-flight (related to the mass-to-charge ratio) along with the charge of individual ions. As a result, this design supports high-throughput metrology of viruses at the single-particle level. The devices and geometry of the instrument have been developed based on ion optics simulations. The performance of the current instrument is demonstrated using human norovirus-like particles (hNoVLP) and Adenovirus Ad(5) (hAdV5).