2024/08/13 by Reisinger, Ellen
#Adeno-assoziierte Viren #DFNB9 #Medicine and health #Otoferlin #adeno-associated viruses #auditorische Synaptopathie #auditory synaptopathy #otoferlin
paper · doi:10.3205/zaud000046
In several clinical studies to date (as of June 2024), more than a dozen children born deaf have been treated with a gene therapy developed specifically for this purpose – and can now hear with their own ears, dance to music, repeat words and answer questions. To achieve this, a gene supplementation therapy was used for children with OTOF-related deafness. This review article explains how well the children hear according to current knowledge and which hearing tests could provide further insights in follow-up studies. Finally, an outlook is given on the broader application of this gene therapy and the gene therapies under development for other forms of deafness.