Chronic social stress induces p16-mediated senescent cell accumulation in mice

2024/11/11 by Carey E. Lyons, Jean Pierre Pallais, Seth McGonigle +12 · 1 voice · 4 citations
Medicine · Biochemistry, Genetics and Molecular Biology · Neuroscience · #Telomeres, Telomerase, and Senescence #Genetics, Aging, and Longevity in Model Organisms #Tryptophan and brain disorders

paper · doi:10.1038/s43587-024-00743-8

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Discussions

• Out today @NatureAging! Life stress can accelerate aging and shorten lifespan, but how remains unclear. We identify that hippocampal/cortical neurons acquire features of p16-dependent #senescence an [bsky, 40 points, 1 comments]