Mouse radial spoke 3 is a metabolic and regulatory hub in cilia

2025/06/27 by Yanhe Zhao, Kangkang Song, Amirrasoul Tavakoli +8 · 1 voice · 7 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Biology #Biophysics #Cell biology #Chemistry #Cilium #Genetic and Kidney Cyst Diseases #Microtubule and mitosis dynamics #Renal and related cancers

paper · doi:10.1038/s41594-025-01594-6

openalex publication_date 2025/06/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Cited by

• Heterogeneity of radial spoke components in Tetrahymena cilia. [europepmc]
• Advances in high-resolution imaging of centrioles and cilia. [europepmc]
• Compartmentalized Nutrient and Hormone Sensing in β-Cells: the Role of Primary Cilia. [europepmc]
• Defective I1 dynein in Chlamydomonas axonemes is epistatic to the RII-binding domain function of radial spoke protein 3 (RSP3) in the regulation of ciliary motility. [europepmc]
• Structure first - exploration and discovery with cryo-electron microscopy. [europepmc]
• The dual molecular identity of vestibular kinocilia bridges structural and functional traits of primary and motile cilia. [europepmc]
• SPEF1 mediates assembly of the central pair microtubule complexes in cilia of Tetrahymena [europepmc]

Discussions

• 🎉 Congrats to Yanhe, Kangkang, @amirtavakoli.bsky.social, Long & co-authors for revealing the atomic structure of RS3, a Giga-sized complex in motile cilia! A tour de force in #cryoET, #cryoEM, #prot [bsky, 41 points, 1 comments]