The global H5N1 influenza panzootic in mammals
2024/09/24 by Thomas P. Peacock, Louise Moncla, Louise H. Moncla +8 · 3 voices · 429 citations
Medicine · #Biology #Influenza A virus subtype H5N1 #Influenza Virus Research Studies #Virology #Virus #Zoology
paper · pdf · doi:10.1038/s41586-024-08054-z
published in Nature 637(8045), 304-313 (Nature Portfolio)
openalex publication_date 2024/09/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06
Citations
Cited by
- H5N1 2.3.4.4b: a review of mammalian adaptations and risk of pandemic emergence
- HPAI drives a fourfold increase in adult gannet mortality which requires two decades recovery time
- Highly pathogenic avian influenza H5N1: history, current situation, and outlook
- Outbreak dynamics of high pathogenicity avian influenza virus H5N1, clade 2.3.4.4b euBB, in black-headed gulls and common terns in Germany in 2023
- Drivers of bat researchers’ intent to adopt field hygiene practices
- Mass mortality events in the sub-Antarctic Indian Ocean caused by long-distance circumpolar spread of highly pathogenic avian influenza H5N1 clade 2.3.4.4b
- Highly pathogenic avian influenza H5N1 in the United States: recent incursions and spillover to cattle
- Controlling bird flu is urgent—for dairy, wildlife, poultry, pets, and people
- Avian Influenza Virus Infections in Felines: A Systematic Review of Two Decades of Literature
- The Arrival of Highly Pathogenic Avian Influenza Viruses in North America, Ensuing Epizootics in Poultry and Dairy Farms and Difficulties in Scientific Naming
- Highlight: comparative single-cell analysis reveals how birds and mammals build distinct lung architectures
- Unique immune and other responses of human nasal epithelial cells infected with H5N1 avian influenza virus compared to seasonal human influenza A and B viruses
- Global risk mapping of highly pathogenic avian influenza H5N1 and H5Nx in the light of epidemic episodes occurring from 2020 onward
- Stability of influenza viruses in the milk of cows and sheep
- Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals
- Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
- Concern for Highly Pathogenic Avian Influenza Spillover into Cetaceans
- Companion animals and H5N1 highly pathogenic avian influenza: cause for concern?
- Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3
- Molecular surveillance and predictive risk modelling of avian influenza virus in wild birds in Egypt
- A modelling assessment of the impact of control measures on highly pathogenic avian influenza transmission in poultry in Great Britain
- The role of wild birds in the global highly pathogenic avian influenza H5 panzootic, 2020–2023
- RNA replicon vaccination confers long-lasting protection against H5N1 avian influenza in 23 zoo bird species
- Challenges in understanding and communicating the risk of zoonotic disease spillover from wild animal meat
- Emergence, migration and spreading of the high pathogenicity avian influenza virus H5NX of the Gs/Gd lineage into America
- Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
- Isolation and characterization of a clade 2.3.4.4b genotype D1.1 H5N1 virus from dairy cattle in Wisconsin
- Stop messing with rumen microbes and focus on reducing ruminant populations for environmental and human health
- Multiple Introductions of Highly Pathogenic Avian Influenza Viruses into the High Arctic: Svalbard and Jan Mayen, 2022–2025
- Avian influenza in Ireland: a spatiotemporal, subtype and host-based analysis (1983–2024)
- Distribution of sialic acids in the bovine mammary gland across different physiological states
- Serological Evidence of Highly Pathogenic Avian Influenza (H5N1) in Invasive Wild Pigs in Western Canada
- Is a human highly pathogenic avian influenza A H5N1 pandemic inevitable?
- Influenza infection of the mammary gland
- The Winners Take It All? Global Evolutionary Success of H5Nx Reassortants in the 2020–2024 Panzootic
- Detection of clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus in a sheep in Great Britain, 2025
- Pandemic risk stemming from the bovine H5N1 outbreak: an account of the knowns and unknowns
- Avian influenza H5N1: A warning signal for the next influenza pandemic
- A VSV-vector vaccine simultaneously targeting H5N1 hemagglutinin and matrix protein 2 induces robust neutralizing and ADCC antibody responses and provides full protection against lethal H5N1 infection in a mouse model
- A high-resolution, US-scale digital similar of interacting livestock, wild birds, and human ecosystems for multihost epidemic spread
- Movement ecology of urban birds: a review of tracking studies
- The Gordon Memorial Lecture: A paradigm shift in high pathogenicity avian influenza and perspectives for the future
- H5N1 avian influenza in dairy cattle: Molecular adaptation, transmission mechanisms, and control strategies
- Global dynamics of avian influenza: a twenty-year analysis of highly pathogenic viruses linking the Caspian Basin, Eurasia and Africa sectors (2005-2025)
- Ongoing H5N1 Outbreaks in Poultry Flocks and Wild Birds in the United States
- Tropism and Replication Competence of Cattle Influenza A(H5N1) Genotype B3.13 Virus in Human Bronchus and Lung Tissue
- On the brink of emergence: an evolutionary approach to Influenza A virus H5N1 isolated from humans
- Detection of clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus in a sheep in Great Britain, 2025
- Cases of human infection with highly pathogenic strains of the avian influenza A virus: risks and vaccination strategies
- Integrated approaches to explore temporal-spatial changes in gene reassortment of highly pathogenic avian influenza A(H5) virus in Eurasia, 2000–2023
- Salpingitis and multiorgan lesions caused by highly pathogenic avian influenza A(H5N1) virus in a cat associated with consumption of recalled raw milk in California
- Modeling of H5N1 influenza virus kinetics during dairy cattle infection suggests the timing of infectiousness
- Emergence of mammalian-adaptive PB2 mutations enhances polymerase activity and pathogenicity of cattle-derived H5N1 influenza A virus
- Influenza A Virus H5N1 Subtype: Resurgent Interspecies and Intercontinental Transmission, and a New Host
- Attachment and replication of clade 2.3.4.4b influenza A (H5N1) viruses in human respiratory epithelium: an in-vitro study
- Resurgence of Zoonotic Highly Pathogenic Avian Influenza A(H5N1) Virus in Cambodia
- Lightweight multiscale early warning system for influenza A spillovers
- Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies
- Isolation of genetically diverse influenza antibodies highlights the role of IG germline gene variation and informs the design of population-comprehensive vaccine strategies
- A veterinary virapalooza: a summary of the 2024 American Society for Virology (ASV) Veterinary/Zoonotic Virology Satellite Symposium and online H5N1 panel discussion
- Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission. [europepmc]
- An influenza mRNA vaccine protects ferrets from lethal infection with highly pathogenic avian influenza A(H5N1) virus. [europepmc]
- Targets of influenza human T-cell response are mostly conserved in H5N1. [europepmc]
- ZBP1-driven cell death in severe influenza. [europepmc]
- Preparedness, prevention and control related to zoonotic avian influenza. [europepmc]
- Pasteurisation temperatures effectively inactivate influenza A viruses in milk. [europepmc]
- Pandemic risk stemming from the bovine H5N1 outbreak: an account of the knowns and unknowns. [europepmc]
- N 6-methyladnosine of vRNA facilitates influenza A virus replication by promoting the interaction of vRNA with polymerase proteins. [europepmc]
- Superior replication, pathogenicity, and immune evasion of a Texas dairy cattle H5N1 virus compared to a historical avian isolate. [europepmc]
- Highly pathogenic avian influenza H5N1: history, current situation, and outlook. [europepmc]
- Dairy cows develop protective immunity against reinfection with bovine H5N1 influenza virus. [europepmc]
- The emergence of highly pathogenic avian influenza H5N1 in dairy cattle: implications for public health, animal health, and pandemic preparedness. [europepmc]
- Avian Influenza Virus Infections in Felines: A Systematic Review of Two Decades of Literature. [europepmc]
- Pathogenicity and transmissibility of bovine-derived HPAI H5N1 B3.13 virus in pigs. [europepmc]
- H5N1 2.3.4.4b: a review of mammalian adaptations and risk of pandemic emergence. [europepmc]
- Highly pathogenic avian influenza H5N1 in the United States: recent incursions and spillover to cattle. [europepmc]
- Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b, Antarctica, 2024. [europepmc]
- Preexisting immunity to the 2009 pandemic H1N1 virus reduces susceptibility to H5N1 infection and disease in ferrets. [europepmc]
- H5N1 virus invades the mammary glands of dairy cattle through 'mouth-to-teat' transmission. [europepmc]
- Emerging threats of HPAI H5N1 clade 2.3.4.4b in swine: knowledge gaps and the imperative for a One Health approach. [europepmc]
- Detection of clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus in a sheep in Great Britain, 2025. [europepmc]
- Circumpolar spread of avian influenza H5N1 to southern Indian Ocean islands. [europepmc]
- Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals. [europepmc]
- The potential of H5N1 viruses to adapt to bovine cells varies throughout evolution. [europepmc]
- Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals. [europepmc]
Discussions