Development of a Si-PM-based high-resolution PET system for small animals

2010/09/16 by Seiichi Yamamoto, Masao Imaizumi, Tadashi Watabe +4 · 11 citations
Medicine · Physics and Astronomy · #Atomic and Subatomic Physics Research #Avalanche photodiode #Detector #Full width at half maximum #Image resolution #Materials science #Medical Imaging Techniques and Applications #Nuclear magnetic resonance #Optics #Optoelectronics #Photodetector #Photodiode #Physics #Radiation Detection and Scintillator Technologies #Resolution (logic) #Scintillator #Silicon photomultiplier

paper · pdf · doi:10.1088/0031-9155/55/19/013

openalex publication_date 2010/09/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Abstract

A Geiger-mode avalanche photodiode (Si-PM) is a promising photodetector for PET, especially for use in a magnetic resonance imaging (MRI) system, because it has high gain and is less sensitive to a static magnetic field. We developed a Si-PM-based depth-of-interaction (DOI) PET system for small animals. Hamamatsu 4 × 4 Si-PM arrays (S11065-025P) were used for its detector blocks. Two types of LGSO scintillator of 0.75 mol% Ce (decay time: ∼45 ns; 1.1 mm × 1.2 mm × 5 mm) and 0.025 mol% Ce (decay time: ∼31 ns; 1.1 mm × 1.2 mm × 6 mm) were optically coupled in the DOI direction to form a DOI detector, arranged in a 11 × 9 matrix, and optically coupled to the Si-PM array. Pulse shape analysis was used for the DOI detection of these two types of LGSOs. Sixteen detector blocks were arranged in a 68 mm diameter ring to form the PET system. Spatial resolution was 1.6 mm FWHM and sensitivity was 0.6% at the center of the field of view. High-resolution mouse and rat images were successfully obtained using the PET system. We confirmed that the developed Si-PM-based PET system is promising for molecular imaging research.

Cited by

• Application of silicon photomultipliers to positron emission tomography. [europepmc]
• A large area, silicon photomultiplier-based PET detector module. [europepmc]
• Evaluation of Matrix9 silicon photomultiplier array for small-animal PET. [europepmc]
• Simulating Silicon Photomultiplier Response to Scintillation Light. [europepmc]
• Characterization of Large-Area SiPM Array for PET Applications. [europepmc]
• Reaching 200-ps timing resolution in a time-of-flight and depth-of-interaction positron emission tomography detector using phosphor-coated crystals and high-density silicon photomultipliers. [europepmc]
• Time-over-threshold for pulse shape discrimination in a time-of-flight phoswich PET detector. [europepmc]
• Ultrahigh resolution radiation imaging system using an optical fiber structure scintillator plate. [europepmc]
• Innovations in Instrumentation for Positron Emission Tomography. [europepmc]
• Performance evaluation of a PET insert for preclinical MRI in stand-alone PET and simultaneous PET-MRI modes. [europepmc]
• Silicon photomultiplier signal readout and multiplexing techniques for positron emission tomography: a review. [europepmc]

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