Aldo-Keto Reductases and Cancer Drug Resistance

2021/07/01 by Trevor M. Penning, T.M. Penning, Sravan Jonnalagadda +3 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Aldose Reductase and Taurine #Epigenetics and DNA Methylation #Cannabis and Cannabinoid Research

paper · pdf · doi:10.1124/pharmrev.120.000122

Citations

• An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies
• Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment

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