Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

2018/06/26 by Panos Zanos, Ruin Moaddel, Patrick J. Morris +9 · 14 citations
Medicine · Neuroscience · #Treatment of Major Depression #Tryptophan and brain disorders #Neuroscience and Neuropharmacology Research

paper · pdf · doi:10.1124/pr.117.015198

Citations

• Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia
• Oral Ketamine and Transdermal Nitroglycerin as Analgesic Adjuvants to Oral Morphine Therapy for Cancer Pain Management
• A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression
• A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
• Ketamine alone and combined with diazepam or xylazine in laboratory animals: a 10 year experience
• Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report
• Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.
• Placebo‐controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression

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• Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
• Ketamine and metabolites in snake venom: effects of venom extraction and potential impact on animal models
• Hallucinogen use in the United States, 2021–2023: Diverging trends and subgroup patterns
• NMDA receptors regulate the firing rate set point of hippocampal circuits without altering single-cell dynamics
• Retrospective Chart Review Evaluating Efficacy and Tolerability of Ketamine Continuous Infusion for Cancer-Related Pain
• A Narrative Review: The Role that Ketamine May Play in the Treatment of Depression and the Underlying Mechanisms of Its Effect
• A single psychotomimetic dose of ketamine decreases thalamocortical spindles and delta oscillations in the sedated rat
• Asymmetric organocatalysis: an enabling technology for medicinal chemistry
• Mechanistic intersections between migraine and major depressive disorder
• Ketamine [wikipedia]