Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis

2005/05/24 by Bruce N. Cronstein · 27 citations
Medicine · #Rheumatoid Arthritis Research and Therapies #Autoimmune and Inflammatory Disorders Research #Acute Lymphoblastic Leukemia research

paper · doi:10.1124/pr.57.2.3

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• Treatment of rheumatoid arthritis
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• The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans. [europepmc]
• Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction. [europepmc]
• Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1. [europepmc]
• Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects. [europepmc]
• The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases. [europepmc]
• Expression of long non-coding RNAs in autoimmunity and linkage to enhancer function and autoimmune disease risk genetic variants. [europepmc]
• Integrating Network Pharmacology and Metabolomics Study on Anti-rheumatic Mechanisms and Antagonistic Effects Against Methotrexate-Induced Toxicity of Qing-Luo-Yin. [europepmc]
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• Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis. [europepmc]
• Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers. [europepmc]
• B Vitamins and One-Carbon Metabolism: Implications in Human Health and Disease. [europepmc]
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• Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies. [europepmc]